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Targeted Inactivation of the Androgen Receptor Gene in Murine Proximal Epididymis Causes Epithelial Hypotrophy and Obstructive Azoospermia

The epithelial lining of the epididymal duct expresses the androgen receptor (Ar) along its entire length and undergoes rapid and profound degeneration when androgenic support is withdrawn. However, experiments involving orchidectomy with systemic testosterone replacement, and testicular efferent du...

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Detalles Bibliográficos
Autores principales: Krutskikh, Anton, De Gendt, Karel, Sharp, Victoria, Verhoeven, Guido, Poutanen, Matti, Huhtaniemi, Ilpo
Formato: Texto
Lenguaje:English
Publicado: Endocrine Society 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101806/
https://www.ncbi.nlm.nih.gov/pubmed/21084446
http://dx.doi.org/10.1210/en.2010-0768