PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells

The activation and regulation of target genes by the tumour-suppressor p53 dictates the fate of a cell, with cell cycle arrest or apoptosis being two distinct outcomes. PERP (p53 apoptosis effector related to PMP-22), a p53 transcriptional target, is induced specifically during apoptosis but not cel...

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Detalles Bibliográficos
Autores principales: Davies, L, Spiller, D, White, M R H, Grierson, I, Paraoan, L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101815/
https://www.ncbi.nlm.nih.gov/pubmed/21451571
http://dx.doi.org/10.1038/cddis.2011.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101815/
https://www.ncbi.nlm.nih.gov/pubmed/21451571
http://dx.doi.org/10.1038/cddis.2011.19

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