Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

To define the mechanisms by which hPrP90-231 induces cell death, we analyzed its interaction with living cells and monitored its intracellular fate. Treatment of SH-SY5Y cells with fluorescein-5-isothiocyanate (FITC)-conjugated hPrP90-231 caused the accumulation of cytosolic aggregates of the prion...

Descripción completa

Detalles Bibliográficos
Autores principales: Thellung, S, Corsaro, A, Villa, V, Simi, A, Vella, S, Pagano, A, Florio, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101817/
https://www.ncbi.nlm.nih.gov/pubmed/21451573
http://dx.doi.org/10.1038/cddis.2011.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101817/
https://www.ncbi.nlm.nih.gov/pubmed/21451573
http://dx.doi.org/10.1038/cddis.2011.21

Ejemplares similares