Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

BACKGROUND: Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and reverses anticancer drug resistance. Cancer stem cells (CSCs) are the major cause of chemoresistance leading to the failure of cancer chemotherapy. This study intended to examin...

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Detalles Bibliográficos
Autores principales: Yip, N C, Fombon, I S, Liu, P, Brown, S, Kannappan, V, Armesilla, A L, Xu, B, Cassidy, J, Darling, J L, Wang, W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101904/
https://www.ncbi.nlm.nih.gov/pubmed/21487404
http://dx.doi.org/10.1038/bjc.2011.126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101904/
https://www.ncbi.nlm.nih.gov/pubmed/21487404
http://dx.doi.org/10.1038/bjc.2011.126

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