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Antiviral Activity of 3(2H)- and 6-Chloro-3(2H)-Isoflavenes against Highly Diverged, Neurovirulent Vaccine-Derived, Type2 Poliovirus Sewage Isolates
BACKGROUND: Substituted flavanoids interfere with uncoating of Enteroviruses including Sabin-2 polio vaccine strains. However flavanoid resistant and dependent, type-2 polio vaccine strains (minimally-diverged), emerged during in vitro infections. Between 1998–2009, highly-diverged (8 to >15%) ty...
Autores principales: | Shulman, Lester M., Sofer, Danit, Manor, Yossi, Mendelson, Ella, Balanant, Jean, Salvati, Anna Laura, Delpeyroux, Francis, Fiore, Lucia |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102060/ https://www.ncbi.nlm.nih.gov/pubmed/21904594 http://dx.doi.org/10.1371/journal.pone.0018360 |
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