Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

BACKGROUND: Increased synthesis of neopterin and degradation of tryptophan to kynurenine, measured as kynurenine/tryptophan ratio (kyn/trp ratio), are considered in vitro markers of interferon beta-1a (IFNβ-1a) activity. The aim of the study was to investigate the dynamic profile of neopterin and ky...

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Detalles Bibliográficos
Autores principales: Durastanti, Valentina, Lugaresi, Alessandra, Bramanti, Placido, Amato, Mariapia, Bellantonio, Paolo, De Luca, Giovanna, Picconi, Orietta, Fantozzi, Roberta, Locatelli, Laura, Solda', Annalisa, Sessa, Edoardo, Totaro, Rocco, Marino, Silvia, Zipoli, Valentina, Zorzon, Marino, Millefiorini, Enrico
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102623/
https://www.ncbi.nlm.nih.gov/pubmed/21501517
http://dx.doi.org/10.1186/1479-5876-9-42

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