New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

BACKGROUND: In an effort to discover new drugs to treat tuberculosis (TB) we chose alanine racemase as the target of our drug discovery efforts. In Mycobacterium tuberculosis, the causative agent of TB, alanine racemase plays an essential role in cell wall synthesis as it racemizes L-alanine into D-...

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Detalles Bibliográficos
Autores principales: Anthony, Karen G., Strych, Ulrich, Yeung, Kacheong R., Shoen, Carolyn S., Perez, Oriana, Krause, Kurt L., Cynamon, Michael H., Aristoff, Paul A., Koski, Raymond A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102704/
https://www.ncbi.nlm.nih.gov/pubmed/21637807
http://dx.doi.org/10.1371/journal.pone.0020374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102704/
https://www.ncbi.nlm.nih.gov/pubmed/21637807
http://dx.doi.org/10.1371/journal.pone.0020374

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