8-Azatetracyclines: Synthesis and Evaluation of a Novel Class of Tetracycline Antibacterial Agents

[Image: see text] A novel series of fully synthetic 8-azatetracyclines was prepared and evaluated for antibacterial activity. Compounds were identified that overcome both efflux (tet(K)) and ribosomal protection (tet(M)) tetracycline resistance mechanisms and are active against Gram-positive and Gra...

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Detalles Bibliográficos
Autores principales: Clark, Roger B., He, Minsheng, Fyfe, Corey, Lofland, Denene, O’Brien, William J., Plamondon, Louis, Sutcliffe, Joyce A., Xiao, Xiao-Yi
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103189/
https://www.ncbi.nlm.nih.gov/pubmed/21302930
http://dx.doi.org/10.1021/jm1015389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103189/
https://www.ncbi.nlm.nih.gov/pubmed/21302930
http://dx.doi.org/10.1021/jm1015389

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