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High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1
Transforming growth factor-β (TGF-β) is an inducer of type I collagen, and uncontrolled collagen production leads to tissue scarring and organ failure. Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. F...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103400/ https://www.ncbi.nlm.nih.gov/pubmed/21471005 http://dx.doi.org/10.1091/mbc.E10-08-0669 |