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High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1

Transforming growth factor-β (TGF-β) is an inducer of type I collagen, and uncontrolled collagen production leads to tissue scarring and organ failure. Here we hypothesize that uncovering a molecular mechanism that enables us to switch off type I collagen may prove beneficial in treating fibrosis. F...

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Detalles Bibliográficos
Autores principales:	Fragiadaki, Maria, Ikeda, Tetsurou, Witherden, Abigail, Mason, Roger M, Abraham, David, Bou-Gharios, George
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103400/ https://www.ncbi.nlm.nih.gov/pubmed/21471005 http://dx.doi.org/10.1091/mbc.E10-08-0669

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