Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

UNC5B acts as a tumor suppressor, and it induces apoptosis in the absence of its cognate ligand netrins. UNC5B is a direct transcriptional target of p53 upon UV stimulation. Here we show that Akt phosphorylates PIKE-A and regulates its association with UNC5B and inhibits UNC5B-provoked apoptosis in...

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Detalles Bibliográficos
Autores principales: He, Kunyan, Jang, Sung-Wuk, Joshi, Jayashree, Yoo, Min-Heui, Ye, Keqiang
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103409/
https://www.ncbi.nlm.nih.gov/pubmed/21460185
http://dx.doi.org/10.1091/mbc.E10-11-0923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103409/
https://www.ncbi.nlm.nih.gov/pubmed/21460185
http://dx.doi.org/10.1091/mbc.E10-11-0923

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