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Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

UNC5B acts as a tumor suppressor, and it induces apoptosis in the absence of its cognate ligand netrins. UNC5B is a direct transcriptional target of p53 upon UV stimulation. Here we show that Akt phosphorylates PIKE-A and regulates its association with UNC5B and inhibits UNC5B-provoked apoptosis in...

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Detalles Bibliográficos
Autores principales:	He, Kunyan, Jang, Sung-Wuk, Joshi, Jayashree, Yoo, Min-Heui, Ye, Keqiang
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103409/ https://www.ncbi.nlm.nih.gov/pubmed/21460185 http://dx.doi.org/10.1091/mbc.E10-11-0923

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