The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements

BACKGROUND: Muscleblind-like 1 (MBNL1) is an alternative splicing factor containing four CCCH Zinc fingers (ZnFs). The sequestration of MBNL1 by expanded CUG and CCUG repeats is a major component in causing myotonic dystrophy. In addition to binding the structured expanded CUG and CCUG repeats; prev...

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Detalles Bibliográficos
Autores principales: Cass, Danielle, Hotchko, Rachel, Barber, Paul, Jones, Kimberly, Gates, Devika P, Berglund, J Andrew
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103431/
https://www.ncbi.nlm.nih.gov/pubmed/21548961
http://dx.doi.org/10.1186/1471-2199-12-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103431/
https://www.ncbi.nlm.nih.gov/pubmed/21548961
http://dx.doi.org/10.1186/1471-2199-12-20

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