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The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements
BACKGROUND: Muscleblind-like 1 (MBNL1) is an alternative splicing factor containing four CCCH Zinc fingers (ZnFs). The sequestration of MBNL1 by expanded CUG and CCUG repeats is a major component in causing myotonic dystrophy. In addition to binding the structured expanded CUG and CCUG repeats; prev...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103431/ https://www.ncbi.nlm.nih.gov/pubmed/21548961 http://dx.doi.org/10.1186/1471-2199-12-20 |