Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition

BACKGROUND: LINE-1s (L1, Long Interspersed Element-1) are the most abundant autonomous non-LTR retrotransposons in the human genome and replicate by reverse transcription of an RNA intermediate. Full-length L1 encodes two open reading frames (ORF1, ORF2) and ORF2 has reverse transcriptase activity....

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Detalles Bibliográficos
Autores principales: Dai, Lixin, Huang, Qing, Boeke, Jef D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103432/
https://www.ncbi.nlm.nih.gov/pubmed/21545744
http://dx.doi.org/10.1186/1471-2091-12-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103432/
https://www.ncbi.nlm.nih.gov/pubmed/21545744
http://dx.doi.org/10.1186/1471-2091-12-18

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