Cargando…

Detailed Analysis of Variants in FTO in Association with Body Composition in a Cohort of 70-Year-Olds Suggests a Weakened Effect among Elderly

BACKGROUND: The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men. BMI is a measure of overweight in relation to the indi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacobsson, Josefin A., Almén, Markus Sällman, Benedict, Christian, Hedberg, Lilia A., Michaëlsson, Karl, Brooks, Samantha, Kullberg, Joel, Axelsson, Tomas, Johansson, Lars, Ahlström, Håkan, Fredriksson, Robert, Lind, Lars, Schiöth, Helgi B.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103532/ https://www.ncbi.nlm.nih.gov/pubmed/21637715 http://dx.doi.org/10.1371/journal.pone.0020158

Ejemplares similares

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924
por: Jacobsson, Josefin A, et al.
Publicado: (2009)

Proof of principle study of a detailed whole-body image analysis technique, “Imiomics”, regarding adipose and lean tissue distribution
por: Lind, Lars, et al.
Publicado: (2019)

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members
por: Sällman Almén, Markus, et al.
Publicado: (2012)

The Origin of GPCRs: Identification of Mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in Fungi
por: Krishnan, Arunkumar, et al.
Publicado: (2012)

Insights into the Origin of Nematode Chemosensory GPCRs: Putative Orthologs of the Srw Family Are Found across Several Phyla of Protostomes
por: Krishnan, Arunkumar, et al.
Publicado: (2014)

Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
por: Rask-Andersen, Mathias, et al.
Publicado: (2011)

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin
por: Almén, Markus Sällman, et al.
Publicado: (2009)

Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae
por: Västermark, Åke, et al.
Publicado: (2011)

The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
por: Almén, Markus Sällman, et al.
Publicado: (2010)

Roux-En Y Gastric Bypass Surgery Induces Genome-Wide Promoter-Specific Changes in DNA Methylation in Whole Blood of Obese Patients
por: Nilsson, Emil K., et al.
Publicado: (2015)

BDNF Polymorphisms Are Linked to Poorer Working Memory Performance, Reduced Cerebellar and Hippocampal Volumes and Differences in Prefrontal Cortex in a Swedish Elderly Population
por: Brooks, Samantha J., et al.
Publicado: (2014)

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children
por: Sällman Almén, M, et al.
Publicado: (2013)

The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
por: Krishnan, Arunkumar, et al.
Publicado: (2014)

Highly diversified expansions shaped the evolution of membrane bound proteins in metazoans
por: Attwood, Misty M., et al.
Publicado: (2017)

Fatty acid composition in serum cholesterol esters and phospholipids is linked to visceral and subcutaneous adipose tissue content in elderly individuals: a cross-sectional study
por: Rosqvist, Fredrik, et al.
Publicado: (2017)

Detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
por: Lind, Lars, et al.
Publicado: (2022)

Impaired Insulin Sensitivity as Indexed by the HOMA Score Is Associated With Deficits in Verbal Fluency and Temporal Lobe Gray Matter Volume in the Elderly
por: Benedict, Christian, et al.
Publicado: (2012)

Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly
por: Titova, Olga E., et al.
Publicado: (2012)

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
por: Olszewski, Pawel K, et al.
Publicado: (2009)

Relationships between plasma levels and six proinflammatory interleukins and body composition using a new magnetic resonance imaging voxel-based technique
por: Strand, Robin, et al.
Publicado: (2020)

Relationships between carotid artery intima-media thickness and echogenicity and body composition using a new magnetic resonance imaging voxel-based technique
por: Lind, Lars, et al.
Publicado: (2021)

Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome
por: Attwood, Misty M., et al.
Publicado: (2016)

Intake of Ultra-Processed Food and Ectopic-, Visceral- and Other Fat Depots: A Cross-Sectional Study
por: Fridén, Michael, et al.
Publicado: (2022)

Serum concentrations of phthalate metabolites are related to abdominal fat distribution two years later in elderly women
por: Lind, P Monica, et al.
Publicado: (2012)

The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients
por: Bandstein, Marcus, et al.
Publicado: (2015)

A concept for holistic whole body MRI data analysis, Imiomics
por: Strand, Robin, et al.
Publicado: (2017)

Associations between fatty acid composition in serum cholesteryl esters and liver fat, basal fat oxidation, and resting energy expenditure: a population-based study
por: Fridén, Michael, et al.
Publicado: (2021)

Associations Between the Prevalence of Metabolic Syndrome and Sleep Parameters Vary by Age
por: Titova, Olga E., et al.
Publicado: (2018)

A whole-body FDG PET/MR atlas for multiparametric voxel-based analysis
por: Sjöholm, Therese, et al.
Publicado: (2019)

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population
por: Lind, Lars, et al.
Publicado: (2020)

The Plasma Metabolomic Profile is Differently Associated with Liver Fat, Visceral Adipose Tissue, and Pancreatic Fat
por: Lind, Lars, et al.
Publicado: (2020)

Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes
por: Drgonova, Jana, et al.
Publicado: (2013)

Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study
por: Rukh, Gull, et al.
Publicado: (2022)

Automatic segmentation of large-scale CT image datasets for detailed body composition analysis
por: Ahmad, Nouman, et al.
Publicado: (2023)

The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children
por: Rask-Andersen, Mathias, et al.
Publicado: (2012)

The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease
por: Voevodskaya, Olga, et al.
Publicado: (2014)

The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors
por: Nordström, Karl JV, et al.
Publicado: (2008)

The G protein-coupled receptor subset of the rat genome
por: Gloriam, David E, et al.
Publicado: (2007)

Magnetic Resonance Imaging Cooling-Reheating Protocol Indicates Decreased Fat Fraction via Lipid Consumption in Suspected Brown Adipose Tissue
por: Lundström, Elin, et al.
Publicado: (2015)

Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents
por: Voisin, Sarah, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fplnfggfl15f6g4c23vepdf155