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IκB kinases increase Myc protein stability and enhance progression of breast cancer cells

BACKGROUND: Both IκB kinase (IKK) complex and oncgenic protein Myc play important roles in cancer progression, including cancer cell invasiveness and metastasis. The levels of Myc is regulated by the phosphorylation of Myc at Thr58 and Ser62. RESULTS: In this study, we show that the expression of My...

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Detalles Bibliográficos
Autores principales: Yeh, Pei-Yen, Lu, Yen-Shen, Ou, Da-Liang, Cheng, Ann-Lii
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104363/
https://www.ncbi.nlm.nih.gov/pubmed/21575199
http://dx.doi.org/10.1186/1476-4598-10-53