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IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition

INTRODUCTION: TGF-β signaling has been extensively studied in many developmental contexts, amongst which is its ability to induce epithelial to mesenchymal transitions (EMT). EMTs play crucial roles during embryonic development and have also come under intense scrutiny as a mechanism through which b...

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Detalles Bibliográficos
Autores principales: Walsh, Logan A, Damjanovski, Sashko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104381/
https://www.ncbi.nlm.nih.gov/pubmed/21535875
http://dx.doi.org/10.1186/1478-811X-9-10