The Essential Functions of NEDD8 Are Mediated via Distinct Surface Regions, and Not by Polyneddylation in Schizosaccharomyces pombe

The ubiquitin-like protein NEDD8 is highly conserved in eukaryotes, from man to Schizosaccharomyces pombe. NEDD8 conjugation to cullin proteins is a prerequisite for cullin based E3 ubiquitin ligase activity, and essential for S. pombe viability. Here, we have performed alanine scanning mutagenesis...

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Detalles Bibliográficos
Autores principales: Girdwood, David, Xirodimas, Dimitris P., Gordon, Colin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105002/
https://www.ncbi.nlm.nih.gov/pubmed/21655279
http://dx.doi.org/10.1371/journal.pone.0020089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105002/
https://www.ncbi.nlm.nih.gov/pubmed/21655279
http://dx.doi.org/10.1371/journal.pone.0020089

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