Biochemical Comparison of Anopheles gambiae and Human NADPH P450 Reductases Reveals Different 2′-5′-ADP and FMN Binding Traits

NADPH-cytochrome P450 oxidoreductase (CPR) plays a central role in chemical detoxification and insecticide resistance in Anopheles gambiae, the major vector for malaria. Anopheles gambiae CPR (AgCPR) was initially expressed in Eschericia coli but failed to bind 2′, 5′-ADP Sepharose. To investigate t...

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Detalles Bibliográficos
Autores principales: Lian, Lu-Yun, Widdowson, Philip, McLaughlin, Lesley A., Paine, Mark J. I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105092/
https://www.ncbi.nlm.nih.gov/pubmed/21655236
http://dx.doi.org/10.1371/journal.pone.0020574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105092/
https://www.ncbi.nlm.nih.gov/pubmed/21655236
http://dx.doi.org/10.1371/journal.pone.0020574

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