BIM-Mediated AKT Phosphorylation Is a Key Modulator of Arsenic Trioxide-Induced Apoptosis in Cisplatin-Sensitive and -Resistant Ovarian Cancer Cells

BACKGROUND: Chemo-resistance to cisplatin-centered cancer therapy is a major obstacle to the effective treatment of human ovarian cancer. Previous reports indicated that arsenic trioxide (ATO) induces cell apoptosis in both drug-sensitive and -resistant ovarian cancer cells. PRINCIPAL FINDINGS: In t...

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Detalles Bibliográficos
Autores principales: Yuan, Zhu, Wang, Fang, Zhao, Zhiwei, Zhao, Xinyu, Qiu, Ji, Nie, Chunlai, Wei, Yuquan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105099/
https://www.ncbi.nlm.nih.gov/pubmed/21655183
http://dx.doi.org/10.1371/journal.pone.0020586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105099/
https://www.ncbi.nlm.nih.gov/pubmed/21655183
http://dx.doi.org/10.1371/journal.pone.0020586

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