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BIM-Mediated AKT Phosphorylation Is a Key Modulator of Arsenic Trioxide-Induced Apoptosis in Cisplatin-Sensitive and -Resistant Ovarian Cancer Cells

BACKGROUND: Chemo-resistance to cisplatin-centered cancer therapy is a major obstacle to the effective treatment of human ovarian cancer. Previous reports indicated that arsenic trioxide (ATO) induces cell apoptosis in both drug-sensitive and -resistant ovarian cancer cells. PRINCIPAL FINDINGS: In t...

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Detalles Bibliográficos
Autores principales:	Yuan, Zhu, Wang, Fang, Zhao, Zhiwei, Zhao, Xinyu, Qiu, Ji, Nie, Chunlai, Wei, Yuquan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105099/ https://www.ncbi.nlm.nih.gov/pubmed/21655183 http://dx.doi.org/10.1371/journal.pone.0020586

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