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Structural basis for the recognition and cleavage of histone H3 by cathepsin L

Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation of cell-cycle progression and cellular differentiation. The recruitment of lysosomal cathepsin L to the nucleus where it mediates proteolysis of the mouse histone H3 tail has been described recently. Here, w...

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Detalles Bibliográficos
Autores principales: Adams-Cioaba, Melanie A., Krupa, Joanne C., Xu, Chao, Mort, John S., Min, Jinrong
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105313/
https://www.ncbi.nlm.nih.gov/pubmed/21326229
http://dx.doi.org/10.1038/ncomms1204