Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif

We report, based on semi-empirical calculations, that Zn(2+) binds duplex DNA containing consecutive FdU–dA base pairs in the major groove with distorted trigonal bipyramidal geometry. In this previously uncharacterized binding motif, O4 and F5 on consecutive FdU are axial ligands while three water...

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Detalles Bibliográficos
Autores principales: Ghosh, Supratim, Salsbury, Freddie R., Horita, David A., Gmeiner, William H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105383/
https://www.ncbi.nlm.nih.gov/pubmed/21296761
http://dx.doi.org/10.1093/nar/gkr029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105383/
https://www.ncbi.nlm.nih.gov/pubmed/21296761
http://dx.doi.org/10.1093/nar/gkr029

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