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Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif
We report, based on semi-empirical calculations, that Zn(2+) binds duplex DNA containing consecutive FdU–dA base pairs in the major groove with distorted trigonal bipyramidal geometry. In this previously uncharacterized binding motif, O4 and F5 on consecutive FdU are axial ligands while three water...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105383/ https://www.ncbi.nlm.nih.gov/pubmed/21296761 http://dx.doi.org/10.1093/nar/gkr029 |