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U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP
U1 Adaptors are a recently reported novel approach for targeted reduction of mRNA transcripts. A U1 adaptor oligonucleotide comprising of a target-complimentary hybridization domain and a U1 recruitment domain, directs the U1 snRNP complex to the terminal exon of a targeted gene, subsequently inhibi...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105408/ https://www.ncbi.nlm.nih.gov/pubmed/21415007 http://dx.doi.org/10.1093/nar/gkr150 |