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Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
Homing endonucleases (HEs) cleave long (∼20 bp) DNA target sites with high site specificity to catalyze the lateral transfer of parasitic DNA elements. In order to determine whether comprehensive computational design could be used as a general strategy to engineer new HE target site specificities, w...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105429/ https://www.ncbi.nlm.nih.gov/pubmed/21288879 http://dx.doi.org/10.1093/nar/gkr022 |