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Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering

Homing endonucleases (HEs) cleave long (∼20 bp) DNA target sites with high site specificity to catalyze the lateral transfer of parasitic DNA elements. In order to determine whether comprehensive computational design could be used as a general strategy to engineer new HE target site specificities, w...

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Detalles Bibliográficos
Autores principales:	Ulge, Umut Y., Baker, David A., Monnat, Raymond J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105429/ https://www.ncbi.nlm.nih.gov/pubmed/21288879 http://dx.doi.org/10.1093/nar/gkr022

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