Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide–gated channels

Cyclic nucleotide–gated (CNG) channels bind cGMP or cAMP in a cytoplasmic ligand–binding domain (BD), and this binding typically increases channel open probability (P(o)) without inducing desensitization. However, the catfish CNGA2 (fCNGA2) subtype exhibits bimodal agonism, whereby steady-state P(o)...

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Detalles Bibliográficos
Autores principales: Wong, Wai-Fung, Chan, Kerry S.C., Michaleski, Matthew S., Haesler, Adam, Young, Edgar C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105518/
https://www.ncbi.nlm.nih.gov/pubmed/21624949
http://dx.doi.org/10.1085/jgp.201010560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105518/
https://www.ncbi.nlm.nih.gov/pubmed/21624949
http://dx.doi.org/10.1085/jgp.201010560

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