A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors

CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract. In the intestine, commensal bacteria conv...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad, Syed, Hughes, Mark A, Lane, Kimberly T, Redinbo, Matthew R, Yeh, Li-An, Scott, John E
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106358/
https://www.ncbi.nlm.nih.gov/pubmed/21643506
http://dx.doi.org/10.2174/1875397301105010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106358/
https://www.ncbi.nlm.nih.gov/pubmed/21643506
http://dx.doi.org/10.2174/1875397301105010013

Ejemplares similares