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A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors

CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract. In the intestine, commensal bacteria conv...

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Detalles Bibliográficos
Autores principales:	Ahmad, Syed, Hughes, Mark A, Lane, Kimberly T, Redinbo, Matthew R, Yeh, Li-An, Scott, John E
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Open 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106358/ https://www.ncbi.nlm.nih.gov/pubmed/21643506 http://dx.doi.org/10.2174/1875397301105010013

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