Cargando…

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

BACKGROUND: Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 receptor ligand SW43 to induce apoptosis and augment standard chemotherapy. RESULT...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hornick, John R, Xu, Jinbin, Vangveravong, Suwanna, Tu, Zhude, Mitchem, Jonathan B, Spitzer, Dirk, Goedegebuure, Peter, Mach, Robert H, Hawkins, William G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106998/ https://www.ncbi.nlm.nih.gov/pubmed/21092190 http://dx.doi.org/10.1186/1476-4598-9-298

Ejemplares similares

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
por: Hornick, John R, et al.
Publicado: (2012)

The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
por: Hashim, Yassar M., et al.
Publicado: (2017)

Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer
por: Garg, Gunjal, et al.
Publicado: (2014)

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma
por: Kashiwagi, Hiroyuki, et al.
Publicado: (2009)

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
por: Xu, Jinbin, et al.
Publicado: (2011)

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic
por: Ohman, Kerri A., et al.
Publicado: (2016)

The targeted SMAC mimetic SW IV-134 augments platinum-based chemotherapy in pre-clinical models of ovarian cancer
por: Binder, Pratibha S., et al.
Publicado: (2022)

Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer
por: Zeng, C, et al.
Publicado: (2013)

Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy
por: Kashiwagi, Hiroyuki, et al.
Publicado: (2007)

Sigma-2 ligands induce tumour cell death by multiple signalling pathways
por: Zeng, C, et al.
Publicado: (2012)

Quantitative Receptor-Based Imaging of Tumor Proliferation with the Sigma-2 Ligand [(18)F]ISO-1
por: Shoghi, Kooresh I., et al.
Publicado: (2013)

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies
por: Ikome, Hermia N., et al.
Publicado: (2016)

Establishment and characterization of the gemcitabine-resistant human pancreatic cancer cell line SW1990/gemcitabine
por: Yu, Yue, et al.
Publicado: (2019)

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent
por: Bagchi, Devika P., et al.
Publicado: (2013)

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
por: Pati, Maria Laura, et al.
Publicado: (2017)

Pancreas Cancer Survival in the Gemcitabine Era
por: Wachtel, Mitchell S., et al.
Publicado: (2008)

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death
por: Zeng, Chenbo, et al.
Publicado: (2019)

Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells
por: Xiao, Jun, et al.
Publicado: (2017)

The Oligomeric States of the Purified Sigma-1 Receptor Are Stabilized by Ligands
por: Gromek, Katarzyna A., et al.
Publicado: (2014)

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer
por: Buchholz, Soeren M., et al.
Publicado: (2020)

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
por: Thejer, Bashar M., et al.
Publicado: (2023)

Pharmacology and Therapeutic Potential of Sigma(1) Receptor Ligands
por: Cobos, E.J, et al.
Publicado: (2008)

Sigma-2 receptor ligands QSAR model dataset
por: Rescifina, Antonio, et al.
Publicado: (2017)

Defining the ligand-dependent proximatome of the sigma 1 receptor
por: Zhao, Jing, et al.
Publicado: (2023)

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
por: Hessmann, E, et al.
Publicado: (2018)

Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer
por: Park, Jun Young, et al.
Publicado: (2018)

Economic evaluation for the UK of nab-paclitaxel plus gemcitabine in the treatment of metastatic pancreas cancer
por: Gharaibeh, M, et al.
Publicado: (2015)

Phase II trial of metformin and paclitaxel for patients with gemcitabine-refractory advanced adenocarcinoma of the pancreas
por: Braghiroli, Maria Ignez, et al.
Publicado: (2015)

Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells
por: Mavlyutov, Timur A, et al.
Publicado: (2007)

Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity
por: Georgiadis, Markos-Orestis, et al.
Publicado: (2017)

Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?
por: Vela, José Miguel
Publicado: (2020)

Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration
por: Cottilli, Patrick, et al.
Publicado: (2022)

Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
por: Dichiara, Maria, et al.
Publicado: (2023)

FELIX and the SW ROD
por: ATLAS TDAQ Collaboration
Publicado: (2021)

Nardoguaianone L Isolated from Nardostachys jatamansi Improved the Effect of Gemcitabine Chemotherapy via Regulating AGE Signaling Pathway in SW1990 Cells
por: Zheng, Yi-Dan, et al.
Publicado: (2022)

Prognostic value of CA 19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine
por: Ziske, C, et al.
Publicado: (2003)

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands
por: Zampieri, Daniele, et al.
Publicado: (2023)

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
por: Longhitano, Lucia, et al.
Publicado: (2017)

Hazards of Using Masking Protocols When Performing Ligand Binding Assays: Lessons From the Sigma-1 and Sigma-2 Receptors
por: Abbas, Haider, et al.
Publicado: (2020)

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology
por: Tatzel, Katharina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_p5vs60db4qbc8oo4r5eveakis1