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DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture
The MHC-II locus encodes a cluster of highly polymorphic genes HLA-DR, -DQ, and -DP that are co-expressed in mature B lymphocytes. Two cell lines were established over 30 years ago from a patient diagnosed with acute lymphocytic leukemia. Laz221 represented the leukemic cells of the patient; whereas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107363/ https://www.ncbi.nlm.nih.gov/pubmed/21326318 http://dx.doi.org/10.1038/gene.2010.77 |