An association study on contrasting cystic fibrosis endophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis disease severity and CFTR mediated residual chloride secretion

BACKGROUND: F508del-CFTR, the most frequent disease-causing mutation among Caucasian cystic fibrosis (CF) patients, has been characterised as a mutant defective in protein folding, processing and trafficking. We have investigated the two neighbouring cytokeratin genes KRT8 and KRT18 in a candidate g...

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Detalles Bibliográficos
Autores principales: Stanke, Frauke, Hedtfeld, Silke, Becker, Tim, Tümmler, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107781/
https://www.ncbi.nlm.nih.gov/pubmed/21548936
http://dx.doi.org/10.1186/1471-2350-12-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107781/
https://www.ncbi.nlm.nih.gov/pubmed/21548936
http://dx.doi.org/10.1186/1471-2350-12-62

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