Cargando…

Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer, suggesting its ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhiwei, Banerjee, Sanjeev, Ahmad, Aamir, Li, Yiwei, Azmi, Asfar S., Gunn, Jason R., Kong, Dejuan, Bao, Bin, Ali, Shadan, Gao, Jiankun, Mohammad, Ramzi M., Miele, Lucio, Korc, Murray, Sarkar, Fazlul H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108612/ https://www.ncbi.nlm.nih.gov/pubmed/21673986 http://dx.doi.org/10.1371/journal.pone.0020537

Ejemplares similares

Hypoxia Induced Aggressiveness of Prostate Cancer Cells Is Linked with Deregulated Expression of VEGF, IL-6 and miRNAs That Are Attenuated by CDF
por: Bao, Bin, et al.
Publicado: (2012)

Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment
por: Bao, Bin, et al.
Publicado: (2012)

Correction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways
Publicado: (2014)

Retraction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways
Publicado: (2018)

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
por: El-Athman, Rukeia, et al.
Publicado: (2017)

Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells
por: Kong, Dejuan, et al.
Publicado: (2010)

Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells
por: Kong, Dejuan, et al.
Publicado: (2012)

Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer
por: Gao, Jiankun, et al.
Publicado: (2014)

Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer
por: Xia, Jun, et al.
Publicado: (2012)

Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer
por: Bao, Bin, et al.
Publicado: (2011)

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors
por: Azmi, Asfar S., et al.
Publicado: (2011)

Pro-oxidant activity of dietary chemopreventive agents: an under-appreciated anti-cancer property
por: Azmi, Asfar S, et al.
Publicado: (2013)

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition (EMT)-Phenotypic Cells: Are They Cousins or Twins?
por: Kong, Dejuan, et al.
Publicado: (2011)

Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis
por: Li, Yiwei, et al.
Publicado: (2012)

Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways
por: Li, Yiwei, et al.
Publicado: (2011)

Targeting MicroRNAs for Personalized Cancer Therapy
por: Li, Yiwei, et al.
Publicado: (2013)

Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells
por: Thakur, Archana, et al.
Publicado: (2012)

Xia, J.; et al., Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer. Int. J. Mol. Sci. 2012, 13, 9627–9641
por: Xia, Jun, et al.
Publicado: (2014)

Progress in Nanotechnology Based Approaches to Enhance the Potential of Chemopreventive Agents
por: Muqbil, Irfana, et al.
Publicado: (2011)

MI-219-Zinc Combination: a new Paradigm in MDM2 Inhibitor Based Therapy
por: Azmi, Asfar S., et al.
Publicado: (2010)

New insights on the regulation of INK4/ARF locus expression
por: Gamell, Cristina, et al.
Publicado: (2017)

Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
por: Farooq, Umer, et al.
Publicado: (2022)

Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics
por: Lang, Liwei, et al.
Publicado: (2017)

INK4a/ARF-dependent senescence upon persistent replication stress
por: O’Driscoll, Mark
Publicado: (2013)

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice
por: Le, Oanh, et al.
Publicado: (2018)

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss
por: Shin, Clifford H., et al.
Publicado: (2017)

Pancreatic Progenitor Commitment Is Marked by an Increase in Ink4a/Arf Expression
por: Montano, Elena, et al.
Publicado: (2021)

Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo
por: Chen, Di, et al.
Publicado: (2012)

The Complexities of Epidemiology and Prevention of Gastrointestinal Cancers
por: Haq, Saba, et al.
Publicado: (2012)

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
por: Bailey, Sean T., et al.
Publicado: (2017)

Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus
por: De Jaime-Soguero, Anchel, et al.
Publicado: (2017)

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
por: Ming, Zizhen, et al.
Publicado: (2020)

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
por: Wagner, Kay-Dietrich, et al.
Publicado: (2022)

Arf6 as a therapeutic target: Structure, mechanism, and inhibitors
por: Sun, Dejuan, et al.
Publicado: (2023)

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
por: Soufir, N, et al.
Publicado: (2004)

MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
por: Culerrier, Raphaël, et al.
Publicado: (2016)

TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background
por: Guijarro, Maria V., et al.
Publicado: (2023)

Notch Signaling in Neuroendocrine Tumors
por: Crabtree, Judy S., et al.
Publicado: (2016)

DNA-Methylation-Caused Downregulation of miR-30 Contributes to the High Expression of XPO1 and the Aggressive Growth of Tumors in Pancreatic Ductal Adenocarcinoma
por: Azmi, Asfar S., et al.
Publicado: (2019)

Non-Coding RNAs in Pancreatic Cancer Diagnostics and Therapy: Focus on lncRNAs, circRNAs, and piRNAs
por: Li, Yiwei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c4qq43aroihhegpcp3ikp2mu1r