Increasing the Analytical Sensitivity by Oligonucleotides Modified with Para- and Ortho-Twisted Intercalating Nucleic Acids – TINA

The sensitivity and specificity of clinical diagnostic assays using DNA hybridization techniques are limited by the dissociation of double-stranded DNA (dsDNA) antiparallel duplex helices. This situation can be improved by addition of DNA stabilizing molecules such as nucleic acid intercalators. Her...

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Detalles Bibliográficos
Autores principales: Schneider, Uffe V., Géci, Imrich, Jøhnk, Nina, Mikkelsen, Nikolaj D., Pedersen, Erik B., Lisby, Gorm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108614/
https://www.ncbi.nlm.nih.gov/pubmed/21673988
http://dx.doi.org/10.1371/journal.pone.0020565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108614/
https://www.ncbi.nlm.nih.gov/pubmed/21673988
http://dx.doi.org/10.1371/journal.pone.0020565

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