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Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease

Huntington's disease (HD) is a progressive neurodegenerative disorder for which there is no effective disease modifying treatment. Following-on from studies in HD animal models, histone deacetylase (HDAC) inhibition has emerged as an attractive therapeutic option. In parallel, several reports h...

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Detalles Bibliográficos
Autores principales: Bobrowska, Anna, Paganetti, Paolo, Matthias, Patrick, Bates, Gillian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108987/
https://www.ncbi.nlm.nih.gov/pubmed/21677773
http://dx.doi.org/10.1371/journal.pone.0020696