Structure of C3PO and Mechanism of Human RISC Activation

Assembly of the RNA-induced silencing complex (RISC) consists of loading duplex (guide/passenger) siRNA onto and removing the passenger strand from Argonaute (Ago2). Ago2 contributes critically to RISC activation by nicking the passenger strand. Here, we reconstituted duplex siRNA-initiated RISC act...

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Detalles Bibliográficos
Autores principales: Ye, Xuecheng, Huang, Nian, Liu, Ying, Paroo, Zain, Huerta, Carlos, Li, Peng, Chen, She, Liu, Qinghua, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109212/
https://www.ncbi.nlm.nih.gov/pubmed/21552258
http://dx.doi.org/10.1038/nsmb.2032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109212/
https://www.ncbi.nlm.nih.gov/pubmed/21552258
http://dx.doi.org/10.1038/nsmb.2032

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