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A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation
INTRODUCTION: Estrogen receptor positive breast cancers often have high levels of Mdm2. We investigated if estrogen signaling in such breast cancers occurred through an Mdm2 mediated pathway with subsequent inactivation of p53. METHODS: We examined the effect of long-term 17β-estradiol (E2) treatmen...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109566/ https://www.ncbi.nlm.nih.gov/pubmed/21223569 http://dx.doi.org/10.1186/bcr2804 |