Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice

INTRODUCTION: Novel adjuvant therapies are needed to prevent metastatic relapses in HER2-expressing breast cancer. Here, we tested whether trastuzumab-selected single-chain Fv (scFv) could be used to develop an anti-idiotype-based vaccine to inhibit growth of HER2-positive tumor cells in vitro and i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ladjemi, Maha Z, Chardes, Thierry, Corgnac, Stephanie, Garambois, Veronique, Morisseau, Sebastien, Robert, Bruno, Bascoul-Mollevi, Caroline, Ait Arsa, Imade, Jacot, William, Pouget, Jean-Pierre, Pelegrin, Andre, Navarro-Teulon, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109586/
https://www.ncbi.nlm.nih.gov/pubmed/21294885
http://dx.doi.org/10.1186/bcr2826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109586/
https://www.ncbi.nlm.nih.gov/pubmed/21294885
http://dx.doi.org/10.1186/bcr2826

Ejemplares similares