Cargando…
Synergistic Interactions between Repeats in Tau Protein and Aβ Amyloids May Be Responsible for Accelerated Aggregation via Polymorphic States
[Image: see text] Amyloid plaques and neurofibrillary tangles simultaneously accumulate in Alzheimer’s disease (AD). It is known that Aβ and tau exist together in the mitochondria; however, the interactions between Aβ oligomers and tau are controversial. Moreover, it is still unclear which specific...
Autores principales: | Miller, Yifat, Ma, Buyong, Nussinov, Ruth |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2011
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109766/ https://www.ncbi.nlm.nih.gov/pubmed/21506544 http://dx.doi.org/10.1021/bi200400u |
Ejemplares similares
-
Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape
por: Miller, Yifat, et al.
Publicado: (2010) -
Polymorphism in Self-Assembly
of Peptide-Based β-Hairpin
Contributes to Network Morphology and Hydrogel Mechanical Rigidity
por: Miller, Yifat, et al.
Publicado: (2014) -
Interactions between Aβ and Mutated Tau Lead to Polymorphism and Induce Aggregation of Aβ-Mutated Tau Oligomeric Complexes
por: Raz, Yoav, et al.
Publicado: (2013) -
Structural
Insight into Tau Protein’s Paradox
of Intrinsically Disordered Behavior, Self-Acetylation Activity, and
Aggregation
por: Luo, Yin, et al.
Publicado: (2014) -
Molecular Recognition between Aβ-Specific Single-Domain Antibody and Aβ Misfolded Aggregates
por: Zhang, Mingzhen, et al.
Publicado: (2018)