Multimeric assembly and biochemical characterization of the Trax/Translin endonuclease complex

Trax/Translin heteromers, also known as C3PO, have been proposed to activate RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. We report on the crystal structure of hexameric Drosophila C3PO formed by truncated Translin and Trax, along with...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Yuan, Simanshu, Dhirendra K., Ascano, Manuel, Diaz-Avalos, Ruben, Park, Ah Young, Juranek, Stefan A., Rice, William J., Yin, Qian, Robinson, Carol V., Tuschl, Thomas, Patel, Dinshaw J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109869/
https://www.ncbi.nlm.nih.gov/pubmed/21552261
http://dx.doi.org/10.1038/nsmb.2069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109869/
https://www.ncbi.nlm.nih.gov/pubmed/21552261
http://dx.doi.org/10.1038/nsmb.2069

Ejemplares similares