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Stochastic dynamics and the evolution of mutations in stem cells
Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110138/ https://www.ncbi.nlm.nih.gov/pubmed/21649942 http://dx.doi.org/10.1186/1741-7007-9-41 |