Stochastic dynamics and the evolution of mutations in stem cells

Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking...

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Detalles Bibliográficos
Autores principales: Dingli, David, Pacheco, Jorge M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110138/
https://www.ncbi.nlm.nih.gov/pubmed/21649942
http://dx.doi.org/10.1186/1741-7007-9-41
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author Dingli, David
Pacheco, Jorge M
author_facet Dingli, David
Pacheco, Jorge M
author_sort Dingli, David
collection PubMed
description Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking into consideration the impact of such mutations on the reproductive fitness of cells. We show how stochastic effects can explain clinical observations, including extinction of acquired clonal stem cell disorders.
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spelling pubmed-31101382011-06-08 Stochastic dynamics and the evolution of mutations in stem cells Dingli, David Pacheco, Jorge M BMC Biol Opinion Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking into consideration the impact of such mutations on the reproductive fitness of cells. We show how stochastic effects can explain clinical observations, including extinction of acquired clonal stem cell disorders. BioMed Central 2011-06-07 /pmc/articles/PMC3110138/ /pubmed/21649942 http://dx.doi.org/10.1186/1741-7007-9-41 Text en Copyright ©2011 Dingli and Pacheco; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Opinion
Dingli, David
Pacheco, Jorge M
Stochastic dynamics and the evolution of mutations in stem cells
title Stochastic dynamics and the evolution of mutations in stem cells
title_full Stochastic dynamics and the evolution of mutations in stem cells
title_fullStr Stochastic dynamics and the evolution of mutations in stem cells
title_full_unstemmed Stochastic dynamics and the evolution of mutations in stem cells
title_short Stochastic dynamics and the evolution of mutations in stem cells
title_sort stochastic dynamics and the evolution of mutations in stem cells
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110138/
https://www.ncbi.nlm.nih.gov/pubmed/21649942
http://dx.doi.org/10.1186/1741-7007-9-41
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