Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death

Huntington’s disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion near the N-terminus of huntingtin. A neuropathological hallmark of Huntington’s disease is the presence of intracellular aggregates composed of mutant huntingtin N-terminal fragments in human postmortem bra...

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Detalles Bibliográficos
Autores principales: Juenemann, Katrin, Weisse, Christina, Reichmann, Denise, Kaether, Christoph, Calkhoven, Cornelis F., Schilling, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110280/
https://www.ncbi.nlm.nih.gov/pubmed/21116768
http://dx.doi.org/10.1007/s12640-010-9227-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110280/
https://www.ncbi.nlm.nih.gov/pubmed/21116768
http://dx.doi.org/10.1007/s12640-010-9227-6

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