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Disease Model Distortion in Association Studies

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a single nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others have...

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Detalles Bibliográficos
Autores principales: Vukcevic, Damjan, Hechter, Eliana, Spencer, Chris, Donnelly, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110308/
https://www.ncbi.nlm.nih.gov/pubmed/21416505
http://dx.doi.org/10.1002/gepi.20576