5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria

Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, the cellular mechanisms underlying impaired brain function are still unclear. Using PAH(enu2) mice (ENU2), the genetic mouse model of PKU, we previously demonstrated that high phenylalanine levels interfere with b...

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Detalles Bibliográficos
Autores principales: Andolina, Diego, Conversi, David, Cabib, Simona, Trabalza, Antonio, Ventura, Rossella, Puglisi-Allegra, Stefano, Pascucci, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2011
Materias:
Thematic Section: Consequences of Developmental Exposure to Drugs, Hormones or Altered Environment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110346/
https://www.ncbi.nlm.nih.gov/pubmed/21040618
http://dx.doi.org/10.1017/S1461145710001288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110346/
https://www.ncbi.nlm.nih.gov/pubmed/21040618
http://dx.doi.org/10.1017/S1461145710001288

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