Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome

The ciliopathy Joubert syndrome is marked by cerebellar vermis hypoplasia, a phenotype for which the pathogenic mechanism is unclear(1–3). In order to investigate Joubert syndrome pathogenesis, we have examined mice with mutated Ahi1, the first identified Joubert syndrome gene(4,5). These mice exhib...

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Detalles Bibliográficos
Autores principales: Lancaster, Madeline A., Gopal, Dipika J., Kim, Joon, Saleem, Sahar N., Silhavy, Jennifer L., Louie, Carrie M., Thacker, Bryan E., Williams, Yuko, Zaki, Maha S., Gleeson, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110639/
https://www.ncbi.nlm.nih.gov/pubmed/21623382
http://dx.doi.org/10.1038/nm.2380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110639/
https://www.ncbi.nlm.nih.gov/pubmed/21623382
http://dx.doi.org/10.1038/nm.2380

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