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Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome
The ciliopathy Joubert syndrome is marked by cerebellar vermis hypoplasia, a phenotype for which the pathogenic mechanism is unclear(1–3). In order to investigate Joubert syndrome pathogenesis, we have examined mice with mutated Ahi1, the first identified Joubert syndrome gene(4,5). These mice exhib...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110639/ https://www.ncbi.nlm.nih.gov/pubmed/21623382 http://dx.doi.org/10.1038/nm.2380 |