Leucine-Rich Repeat Kinase 2 Modulates Retinoic Acid-Induced Neuronal Differentiation of Murine Embryonic Stem Cells

BACKGROUND: Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein. LRRK2 is expressed in neural precursor cells suggesting a role in neurodevelopment. METHO...

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Detalles Bibliográficos
Autores principales: Schulz, Cathrin, Paus, Marie, Frey, Katharina, Schmid, Ramona, Kohl, Zacharias, Mennerich, Detlev, Winkler, Jürgen, Gillardon, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111438/
https://www.ncbi.nlm.nih.gov/pubmed/21695257
http://dx.doi.org/10.1371/journal.pone.0020820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111438/
https://www.ncbi.nlm.nih.gov/pubmed/21695257
http://dx.doi.org/10.1371/journal.pone.0020820

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